The significance of anticardiac autoantibodies in children with bradyarrhythmias

The significance of autoimmune mechanisms in the pathogenesis of cardiac arrhythmias and conduction disorders in children remains poorly understood, the prognostic significance of changes of the prognostic significance antibodies level to different myocardial structures in children with bradyarrhythmias has not been fully determined. This study presents data from 105 children who underwent cardiological examination and analysis of anticardiac antibody levels. It was found that, that elevated and high levels of anticardiac antibodies are detected in 50% among children with bradyarrhythmias, the antibody titer to the cardiac conduction system 1:160 was registered in 22% of children, and 1:320 and higher — in 18% of children. Elevated and high titers of anticardiac antibodyies are associated with delay of the electrical systole of the ventricles and a tendency to decrease the contractility of the heart.