Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats
This study reveals that cardiomyocyte-derived exosomes transport miR-181a-5p, facilitating heart-brain crosstalk and exacerbating MA CPP behavior in rats. These effects are mediated through the regulation of key brain targets, including HSP90B1, TNF, and MAP2K1, providing new insights into the molecular mechanisms of MA addiction and potential therapeutic targets.
Authors
- Peng You (ORCID: https://orcid.org/0000-0003-0285-7844)
- Jieyu Li (ORCID: https://orcid.org/0000-0002-9147-3756)
- Hancheng Li (ORCID: https://orcid.org/0000-0002-5963-1494)
- Zhixian Mo (ORCID: https://orcid.org/0000-0002-4100-7298)
- Chaohua Luo (ORCID: https://orcid.org/0000-0002-2967-1399)
- Yi‐Ling Chen (ORCID: https://orcid.org/0000-0002-9789-2441)
- Hongwu Wang (ORCID: https://orcid.org/0000-0001-6401-977X)
- Ying Hé (ORCID: https://orcid.org/0000-0001-8667-3107)
- Yangkai Wu
Institutions
- Zhaoqing University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3389/fphar.2025.1541442
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China