A highly efficient heterologous expression platform to facilitate the production of microbial natural products in Streptomyces
We demonstrated that our Micro-HEP system enables the efficient expression of foreign BGCs, facilitating the discovery of new NPs and increasing yields.
Authors
- Xueyan Feng
- You‐Ming Zhang (ORCID: https://orcid.org/0000-0001-5722-1347)
- Jun Fu (ORCID: https://orcid.org/0000-0002-5120-4674)
- Cailing Ren
- Ping Lin (ORCID: https://orcid.org/0000-0001-5714-8071)
- Liujie Huo (ORCID: https://orcid.org/0000-0002-1406-8466)
- Shouying Xu (ORCID: https://orcid.org/0000-0002-0820-0141)
- Gang Li (ORCID: https://orcid.org/0000-0003-0621-2779)
- Ruijuan Li (ORCID: https://orcid.org/0000-0002-2278-4622)
- Qiong Duan (ORCID: https://orcid.org/0000-0002-2957-5129)
- Daojing Yong
- Qijun Zhang (ORCID: https://orcid.org/0000-0003-1315-4765)
- Xiuling Wang (ORCID: https://orcid.org/0000-0002-2227-8295)
- Yang Liu (ORCID: https://orcid.org/0000-0002-1015-6346)
- Qiyao Shen
Institutions
- Qingdao University (CN)
- Shandong University (CN)
- State Key Laboratory of Microbial Technology
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s12934-025-02722-z
- Citations
- 3
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Shandong University
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China