Transfer of Herpes Simplex Virus Type 1 (HSV-1) Specific T Cells in a Pediatric Patient Post-HSCT With Severe, Acyclovir-resistant HSV-1 Infection
Herpes simplex virus (HSV) reactivation and acyclovir resistance are common complications in immunocompromised individuals. We report a pediatric hematopoietic stem cell transplantation (HSCT) recipient who received HSV-1-specific T cells from a partially human leukocyte antigen (HLA) matched donor for severe acyclovir-resistant HSV-1 mucositis resulting in clinical improvement, reduced plasma viral load, and emergence of antiviral T cells.
Authors
- Rita Beier (ORCID: https://orcid.org/0000-0002-7568-8749)
- Britta Eiz‐Vesper (ORCID: https://orcid.org/0000-0001-8378-3298)
- Albert Heim (ORCID: https://orcid.org/0000-0002-9447-1561)
- Britta Maecker‐Kolhoff (ORCID: https://orcid.org/0000-0001-8164-514X)
- Rebecca Schultze-Florey (ORCID: https://orcid.org/0000-0003-3293-2550)
- Astrid Wintering (ORCID: https://orcid.org/0000-0002-3731-6928)
- Martin Sauer (ORCID: https://orcid.org/0000-0001-6221-9081)
- Ariana de Oliveira Mekonnen
- Sabine Tischer-Zimmermann (ORCID: https://orcid.org/0000-0003-2326-0342)
- Agnes Bonifacius (ORCID: https://orcid.org/0000-0002-0112-967X)
- De Werner
Institutions
- Medizinische Hochschule Hannover (DE)
- German Center for Infection Research (DE)
- Institute of Virology of the Slovak Academy of Sciences (SK)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1093/cid/ciaf125
- Citations
- 1
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.35