Relación entre el consumo de café y el cáncer gástrico: protocolo de una revisión tipo sombrilla

Summary: Introduction: Cancer encompasses several diseases arising from the uncontrolled growth of abnormal cells. Meanwhile, biological mechanisms have been studied by which certain components of coffee possess antioxidant,2antiangiogenic, and modulation properties of pathways regulating tumor growth. Objective: To compile, analyze, and summarize evidence on the effect of regular coffee consumption on gastric cancer incidence. Methods: An umbrella review will be conducted with a search for meta-analyses and systematic reviews in databases such as EMBASE, PubMed, Cochrane, and Lilacs from inception to February 2023; grey literature will be included. Article quality assessment will use the AMSTAR 2 tool (Assessing the methodological quality of systematic reviews). The search, selection, and data extraction will be independently performed by a pair of researchers, and discrepancies will be resolved through consensus. Discussion: Synthesizing evidence on the effect of regular coffee consumption on gastric cancer incidence will help address gaps in both knowledge and clinical practice.