Fully automated MRI‐based analysis of the locus coeruleus in aging and Alzheimer's disease dementia using ELSI‐Net
We provide a thorough evaluation of a fully automatic locus coeruleus (LC) segmentation method termed Ensemble-based Locus Coeruleus Segmentation Network (ELSI-Net) in aging and Alzheimer's disease (AD) dementia.ELSI-Net outperforms previous work and shows high agreement with manual ratings and previously published LC atlases.ELSI-Net replicates previously shown LC group differences in aging and AD.ELSI-Net's LC mask volume correlates with cerebrospinal fluid biomarkers of AD pathology.
Authors
- Emrah Düzel (ORCID: https://orcid.org/0000-0002-0139-5388)
- Steffen Oeltze‐Jafra (ORCID: https://orcid.org/0000-0002-6962-9080)
- Ayda Rostamzadeh (ORCID: https://orcid.org/0000-0001-5189-134X)
- Annika Spottke (ORCID: https://orcid.org/0000-0001-9854-2972)
- Alessandro Sciarra (ORCID: https://orcid.org/0000-0002-7899-8056)
- Stefan Johannes Teipel (ORCID: https://orcid.org/0000-0002-3586-3194)
- Frederic Brosseron (ORCID: https://orcid.org/0000-0003-3137-7516)
- Johanna Brustkern (ORCID: https://orcid.org/0000-0001-5204-1013)
- Klaus Fließbach (ORCID: https://orcid.org/0000-0002-0183-7510)
- Enise Irem Incesoy (ORCID: https://orcid.org/0000-0003-2014-4098)
- Matthew J. Betts (ORCID: https://orcid.org/0000-0002-2840-4678)
- Okka Kimmich (ORCID: https://orcid.org/0009-0008-2119-7590)
- Max Dünnwald (ORCID: https://orcid.org/0000-0003-3838-3345)
- Frank Jessen (ORCID: https://orcid.org/0000-0003-1067-2102)
- Ingo Kilimann (ORCID: https://orcid.org/0000-0002-3269-4452)
- Anja Schneider (ORCID: https://orcid.org/0000-0001-9540-8700)
- Michael T. Heneka (ORCID: https://orcid.org/0000-0003-4996-1630)
- Friedrich Krohn (ORCID: https://orcid.org/0000-0001-8852-0753)
- Wenzel Glanz (ORCID: https://orcid.org/0000-0002-5865-4176)
- Falk Lüsebrink (ORCID: https://orcid.org/0000-0001-5770-0727)
- Dorothea Hämmerer
- Klaus Tönnies
- Mousumi Sarkar
- Doreen Göerß
Institutions
- University of Bonn (DE)
- University of Cologne (DE)
- University of Luxembourg (LU)
- Universität Innsbruck (AT)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- Medizinische Hochschule Hannover (DE)
- Center for Behavioral Brain Sciences (DE)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- University Hospital Magdeburg (DE)
- University College London (GB)
- University of Rostock (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/dad2.70118
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- EU Joint Programme – Neurodegenerative Disease Research
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- National Institutes of Health