Risk stratification and conservative management of women aged 25–40 years with cervical intraepithelial neoplasia grade 2(CIN2)

Patients aged 25-40 years with CIN2 diagnosed in punch biopsy exhibited a substantial risk of CIN3⁺ in LEEP specimens, warranting consideration for surgical intervention, particularly in those with HPV16/18 and HSIL cytology. Approximately 30% of CIN2 patients with HPV16/18 and ASC-US/LSIL, or other high-risk HPV types and HSIL cytology, also showed CIN3⁺, suggesting that treatment should be individualized considering the patient's preferences and adherence. Conversely, the risk was low for those with HPV16/18 and normal cytology or other high-risk HPV types and ASC-US/LSIL, making conservative management a viable option. .