GsMTx4-blocked PIEZO1 channel promotes myogenic differentiation and alleviates myofiber damage in Duchenne muscular dystrophy
PIEZO1 upregulation in DMD could potentially stem from an elevated proportion of proliferating satellite cells triggered by sarcolemma damage and muscle necrosis. The inhibition of the PIEZO1 channel by GsMTx4 plays a beneficial role in fostering myogenic differentiation and mitigating myofiber damage. The PIEZO1 channel emerges as a promising therapeutic target for addressing DMD.
Authors
- Ming Luo (ORCID: https://orcid.org/0000-0002-5474-3892)
- Ningning Yang (ORCID: https://orcid.org/0000-0003-0691-7293)
- Wengang Wang (ORCID: https://orcid.org/0000-0001-6376-7004)
- Xiusheng Huang
- Ke Ma (ORCID: https://orcid.org/0000-0001-9184-3422)
- Mingyang Huang
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s13395-025-00383-5
- Citations
- 6
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China