Narciclasine enhances cisplatin-induced apoptotic cell death by inducing unfolded protein response-mediated regulation of NOXA and MCL1
We identified a natural product, narciclasine, that synergizes with cisplatin. The combination of cisplatin and narciclasine induced NOXA expression, downregulated MCL1, and ultimately induced apoptosis in NSCLC tumor spheroids. Our findings suggest that narciclasine is a potential natural product for combination with cisplatin for treatment of NSCLC.
Authors
- Yong-Nyun Kim
- Ji Hae Lee (ORCID: https://orcid.org/0000-0002-5132-1627)
- Seung Hee Seo (ORCID: https://orcid.org/0000-0002-7755-7363)
- Kyungsil Yoon
- Jaegal Shim (ORCID: https://orcid.org/0000-0002-2327-8238)
Institutions
- Ewha Womans University (KR)
- National Cancer Center (US)
- National Cancer Center (KR)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s11658-025-00735-5
- Citations
- 3
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.42