Influence of time delay on the dynamics of a mathematical model of CAR-T cell therapy with logistic tumor growth
We consider a model of CAR-T therapy for glioblastoma, focusing on the influence of time needed for an immune reaction to be triggered. This results in a system of delay differential equations which we investigate, studying the main properties of the model, including the number of steady states and their stability depending on the delay magnitude. Numerical simulations illustrate analytical results. We interpret mathematical results and formulate biological insights.
Authors
- Monika Joanna Piotrowska (ORCID: https://orcid.org/0000-0003-0156-8290)
- Urszula Foryś (ORCID: https://orcid.org/0000-0002-6198-3667)
- Marek Bodnar (ORCID: https://orcid.org/0000-0001-5571-2476)
- Juan Belmonte-Beitia (ORCID: https://orcid.org/0000-0002-5003-1150)
- Mateusz Krukowski (ORCID: https://orcid.org/0000-0001-6644-5633)
- Magdalena Szafrańska-Łęczycka
Institutions
- Lodz University of Technology (PL)
- Institute of Mathematics (PL)
- University of Warsaw (PL)
- University of Castilla-La Mancha (ES)
Publication Details
- Journal
- Discrete and Continuous Dynamical Systems - B
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3934/dcdsb.2025073
- Citations
- 3
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Ministerio de Ciencia e Innovación
- Uniwersytet Warszawski
- Universidad de Castilla-La Mancha
- Junta de Comunidades de Castilla-La Mancha
- European Regional Development Fund