Research Advances on IL-1<i>β</i> and IL-6 in Chronic Atrophic Gastritis and Primary Sjögren’s Syndrome

慢性萎缩性胃炎(chronic atrophic gastritis, CAG)以胃黏膜固有腺体萎缩为主要特征，是消化系统的常见病、多发病。原发性干燥综合症(primary sjogren syndrome, pSS)是一种主要累及外分泌腺体的自身免疫性疾病，约80%的pSS并发CAG，提示CAG与pSS的发病可能具有同源性。本文从细胞因子(cytokine, CK)方面寻找突破口，就CAG、pSS中主要失调的CK——白细胞介素1β (IL-1β)、白细胞介素6 (IL-6)作一综述，揭示每种CK与疾病的相关性及在疾病中的作用，旨在为CAG及pSS并发CAG的发生机制提供新思路。Chronic atrophic gastritis (CAG), characterized by atrophy of the gastric mucosal intrinsic glands, is a common and frequently occurring disease of the digestive system. Primary Sjögren’s syndrome (pSS) is an autoimmune disorder primarily affecting exocrine glands, and approximately 80% of pSS patients are complicated with CAG, suggesting a potential shared pathogenesis between CAG and pSS. This review explores cytokines (CKs) as a breakthrough point, focusing on the predominantly dysregulated CKs in CAG and pSS—interleukin-1β (IL-1β) and interleukin-6 (IL-6). It elucidates the correlation of each cytokine with these diseases and their roles in disease progression, aiming to provide novel insights into the mechanisms underlying CAG and its comorbidity with pSS.