Experimental Research Progress on the Intervention of Epilepsy with Traditional Chinese Medicine in the Past Five Years

Epilepsy is a common chronic and recurrent neurological disorder characterized by abnormal neurological dysfunction, severely impacting quality of life and endangering human health. In recent years, the role and advantages of Traditional Chinese Medicine (TCM) in treating epilepsy have become increasingly prominent. This article aims to review experimental research progress on TCM-based treatments for epilepsy over the past five years, with the goal of providing stronger data support for future clinical practice and research. Epilepsy primarily refers to a group of clinical syndromes caused by highly synchronized abnormal discharges of neurons in the brain, characterized by episodic, transient, stereotyped, and recurrent features. It severely impacts patients' quality of life and psychological well-being. Consequently, effectively controlling epileptic seizures and clarifying the pathogenesis have long been critical concerns. However, the underlying mechanisms of epilepsy remain incompletely elucidated, with current hypotheses focusing on neuroinflammation, oxidative stress, microglial activation, and imbalances in neurotransmitter metabolism [1]. Research on the prevention and treatment of epilepsy using Traditional Chinese Medicine (TCM) has spanned decades. This article reviews recent experimental advances in the intervention of epilepsy using active ingredients derived from Chinese herbal medicine.