Biological Ageing and the Risk of Inflammatory Bowel Disease: Exploring the Role of Lifestyle and Genetic Susceptibility in a Nationwide Prospective Study
PhenoAge acceleration may serve as a useful biomarker for identifying high-risk individuals, offering potential for integration into targeted prevention strategies and personalized treatment approaches for IBD.This study explores how accelerated biological aging (PhenoAge acceleration) and genetic susceptibility influence the risk of inflammatory bowel disease. Findings indicate that higher PhenoAge acceleration and genetic risk scores significantly increase the likelihood of developing ulcerative colitis and Crohn's disease.
Authors
- Changxue Li
- Yuquan Chen (ORCID: https://orcid.org/0000-0001-5792-6566)
- Chi Hao (ORCID: https://orcid.org/0000-0002-5778-7348)
- Qi Zhang (ORCID: https://orcid.org/0000-0001-9916-8919)
- Jiarong He (ORCID: https://orcid.org/0000-0002-1261-1672)
- Hui Wang (ORCID: https://orcid.org/0000-0001-7452-3558)
- Zining Luo (ORCID: https://orcid.org/0009-0004-7771-4623)
- Mingming Zhang (ORCID: https://orcid.org/0009-0002-7519-1043)
- Ming Wang
Institutions
- North Sichuan Medical University (CN)
- Central South University (CN)
- Southwest Medical University (CN)
- Taishan University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Monash University (AU)
- University of South China (CN)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1093/ibd/izaf106
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Natural Science Foundation of Hainan Province
- Fundamental Research Funds for Central Universities of the Central South University