Association between 8-oxoguanine glycosylase 1 polymorphism and some markers of liver detoxification in people living with human immunodeficiency virus

Introduction: Single nucleotide polymorphisms in 8-oxoguanine glycosylase 1 (OGG1) gene play protective role against 8-hydroxy-2-deoxyguanosine (8-OHdG) mutation, and may influence individual's response to treatment in human immunodeficiency virus (HIV) infection.The current study determined the impact of OGG1 polymorphisms on some markers of liver function and antioxidants among people living with HIV (PLWH). Material and methods:This cross-sectional study was conducted among 200 HIV-positive individuals, attending outpatient clinic dedicated to PLWH of Ladoke Akintola University of Technology Teaching Hospital (LAUTECH), Osogbo, Nigeria, and 100 HIV-negative subjects as controls.A structured questionnaire was administered to collect relevant medical and socio-demographic data.Multistage random technique was employed in enrolling subjects for the study.Serum glucose, total protein, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), vitamin E, and glutathione reductase (GR), were determined using spectrophotometric and enzyme-linked immunosorbent assay methods.Data were analyzed with Student's t-test, c 2 test, analysis of variance, and Pearson's correlation coefficient.Results: ALT (p < 0.002) and AST (p < 0.001) were significantly higher, while GR (p < 0.008) and vitamin E (p < 0.01) were significantly lower among patients with OGG1 genotype CC than those with genotypes GG + CC.ALT (p < 0.033) was significantly higher, and GR (p < 0.001) was significantly higher among subjects with viral load below 1,000 copies than those with viral load above 1,000 copies. Conclusions:The findings of this study suggest that single nucleotide polymorphism in OGG1 gene may play significant role in individual's response to antiretroviral drugs and disease progression, and patients with genotype CC are likely to response poorly compared with those with GG and CC genotypes.