Refinement of primary central nervous system lymphoma prognostication and response assessment using 3-dimensional MRI
Although PCNSL tumor 3DV at baseline is not associated with survival outcomes, 3DVR of ≥58% in interim and EOT confers superior PFS and OS. Whereas, no difference in survival was observed using standard 2D CR versus PR response assessment at the same time-points. 3DV calculations may offer a sensitive method of response assessment for PCNSL. We are currently validating this in clinical trials.
Authors
- Eliza A. Hawkes (ORCID: https://orcid.org/0000-0002-0376-2559)
- Leonid P. Churilov (ORCID: https://orcid.org/0000-0002-9807-6606)
- Sze Ting Lee (ORCID: https://orcid.org/0000-0001-8641-456X)
- Shivam Agrawal
- Gareth Peter Gregory (ORCID: https://orcid.org/0000-0002-4170-0682)
- Michael Wang (ORCID: https://orcid.org/0000-0003-0421-675X)
- Maciej Tatarczuch (ORCID: https://orcid.org/0000-0002-5335-4481)
- Joyce O’Shaughnessy (ORCID: https://orcid.org/0000-0001-6764-2807)
- Arina Martynchyk (ORCID: https://orcid.org/0009-0009-3094-8867)
- Geoffrey Chong (ORCID: https://orcid.org/0000-0003-4006-2380)
- Colm Keane (ORCID: https://orcid.org/0000-0002-9009-9934)
- Nariza Alysa Azryn
Institutions
- The University of Queensland (AU)
- The University of Melbourne (AU)
- Monash Health (AU)
- Olivia Newton-John Cancer Wellness & Research Centre (AU)
- Austin Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/noajnl/vdaf090
- Primary Topic
- CNS Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00