The relationship between neurofilament light chain and depressive symptoms according to cognitive status
Plasma neurofilament light (NfL) levels might be associated with 15-Geriatric Depression Scale (GDS-15) scores only among people with Clinical Dementia Rating (CDR) 0.5 (indicative of mild cognitive impairment [MCI]), but not among those with CDR 0 (normal cognition).Depressive symptoms arising in the context of cognitive impairment may represent a distinct clinical entity compared to those observed in individuals with normal cognitive functioning.Further research with larger sample sizes is needed to elucidate potential biological differences in depressive symptoms across varying cognitive statuses (unimpaired cognition, MCI, and dementia).
Authors
- Jérémy Raffin
- Davide Angioni (ORCID: https://orcid.org/0000-0003-3253-2522)
- Federico Bellelli (ORCID: https://orcid.org/0000-0001-8801-0294)
- Philipe De Souto Barreto
- María Soto
- Julien Delrieu
- Julie Romana
Institutions
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- University of Milan (IT)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Institut Pasteur de la Guadeloupe (GP)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/trc2.70048
- Citations
- 1
- Primary Topic
- Eating Disorders and Behaviors
- Type
- article
- Field-Weighted Citation Impact
- 2.31
Funders
- Les Laboratories Pierre Fabre
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Centre Hospitalier Universitaire de Toulouse
- Avid Radiopharmaceuticals