[A new triterpenoid from Elephantopus scaber].

The chemical constituents of the petroleum ether extract derived from the 90% ethanol extract of Elephantopus scaber were investigated. By silica gel column chromatography, C_(18), MCI column chromatography and semi-preparative high performance liquid chromatography, ten compounds were isolated. Their structures were identified as 3β-hydroxy-6β,7β-epoxytaraxeran-14-ene(1), 3β-hydroxyolean-12-en-28-oic acid(2), D-friedoolean-14-ene-3β,7α-diol(3), 3β-hydroxy-11α-methoxyolean-12-ene(4), 3β-hydroxyolean-11,13(18)-diene(5), 11α-hydroxy-β-amyrin(6), betulinic acid(7), 3β-hydroxy-30-norlupan-20-one(8), 6-acetonylchelerythrine(9), and 4',5'-dehydrodiodictyonema A(10) by analysis of the 1D NMR, 2D NMR, MS, and IR spectral data. Among them, compound 1 was a new triterpene and other compounds except compounds 2 and 7 were isolated from this plant for the first time.

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Publication Details

Journal
PubMed
Published
2025-03-01
DOI
https://doi.org/10.19540/j.cnki.cjcmm.20241216.201
Primary Topic
Natural product bioactivities and synthesis
Type
article
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[A new triterpenoid from Elephantopus scaber].

Junjie Hao, Lin Chen, Zhi‐Yong Jiang, Zhangfeng Ding et al.
PubMed
Natural product bioactivities and synthesis
article

[A new triterpenoid from Elephantopus scaber].

Junjie Hao, Lin Chen, Zhi‐Yong Jiang, Zhangfeng Ding, Yu Luo, Hong-Xi Xie, Shi-Kui Xu
article en

Abstract

The chemical constituents of the petroleum ether extract derived from the 90% ethanol extract of Elephantopus scaber were investigated. By silica gel column chromatography, C_(18), MCI column chromatography and semi-preparative high performance liquid chromatography, ten compounds were isolated. Their structures were identified as 3β-hydroxy-6β,7β-epoxytaraxeran-14-ene(1), 3β-hydroxyolean-12-en-28-oic acid(2), D-friedoolean-14-ene-3β,7α-diol(3), 3β-hydroxy-11α-methoxyolean-12-ene(4), 3β-hydroxyolean-11,13(18)-diene(5), 11α-hydroxy-β-amyrin(6), betulinic acid(7), 3β-hydroxy-30-norlupan-20-one(8), 6-acetonylchelerythrine(9), and 4',5'-dehydrodiodictyonema A(10) by analysis of the 1D NMR, 2D NMR, MS, and IR spectral data. Among them, compound 1 was a new triterpene and other compounds except compounds 2 and 7 were isolated from this plant for the first time.

PubMedVol. 50(5)
Yunnan University (CN), Kunming Medical University (CN), Yunnan Institute For Drug Abuse (CN), Yunnan University of Traditional Chinese Medicine (CN)
Natural product bioactivities and synthesis
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[A new triterpenoid from Elephantopus scaber]. — Junjie Hao, Lin Chen, et al. · PubMed (2025) | TGRS Research Map | TGRS