Lag3 and PD-1 pathways preferentially regulate NFAT-dependent TCR signalling programmes during early CD4+ T cell activation
Our data therefore reveal that PD-1 and Lag3 pathways converge to additively regulate TCR signal duration and may preferentially control NFAT-dependent transcriptional activity during early CD4<sup>+</sup> T cell re-activation.
Authors
- Elizabeth Jinks
- David A.J. Lecky (ORCID: https://orcid.org/0000-0002-9333-5605)
- Sophie Rouvray (ORCID: https://orcid.org/0009-0008-8828-1447)
- Lozan Sheriff (ORCID: https://orcid.org/0000-0001-8364-9080)
- Lalit Pallan (ORCID: https://orcid.org/0000-0003-1112-4829)
- Emma Jennings (ORCID: https://orcid.org/0000-0002-0892-4756)
- Alastair Copland (ORCID: https://orcid.org/0000-0003-3117-3935)
- Thomas A.E. Elliot (ORCID: https://orcid.org/0000-0001-9292-2472)
- David Bending (ORCID: https://orcid.org/0000-0003-0071-1163)
- Reygn Done (ORCID: https://orcid.org/0009-0004-7811-8313)
- L. George
Institutions
- University of Birmingham (GB)
Publication Details
- Journal
- Immunotherapy Advances
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1093/immadv/ltaf015
- Citations
- 1
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Lister Institute of Preventive Medicine
- Medical Research Council