Secondary cutaneous diffuse large B-Cell lymphomas: bad scenario

Primary or secondary cutaneous involvement may occur in common diffuse large B-cell lymphomas. The secondary cutaneous involvement of diffuse large B-cell lymphoma is a condition that develops during the course of the disease and is associated with an aggressive course and shorter survival. The development of secondary cutaneous involvement shortly after the initial diagnosis of the primary disease predicts more aggressive clinical outcomes and is more likely to present with multiple skin lesions.