Research Progress on the Synthesis of Sulfonyl Fluoride Compounds Based on Small Molecule Sulfur-Fluoride Building Blocks

The sulfur-fluoride exchange click chemistry, as an emerging synthetic technique, has developed rapidly since its inception in 2014.Leveraging the sulfonyl fluoride group, this technology enables efficient and rapid synthesis of sulfonyl compounds.Sulfonyl fluorides, owing to their unique electrophilic properties, have found widespread applications in fields such as organic synthesis, chemical biology, new drug discovery, and novel material development.In recent years, sulfur-fluoride exchange click chemistry not only has facilitated the synthesis of high-value sulfur-fluoride compounds but also has been successfully applied in the research of anti-tumor, anti-bacterial, anti-oxidant, and other drugs, significantly enhancing the biological activity of these medications.Drawing upon the design and development of small-molecule sulfur-fluoride building blocks, the author provides a detailed account of the synthesis of sulfonyl fluorides in recent years.As key intermediates, sulfonyl fluorides will play a pivotal role in numerous high-tech sectors, driving the continuous advancement of chemistry, materials science, and biomedical research.