Advances of Asymmetric Synthesis Combining of Gold and Chiral Phosphoric Acid Catalysts

Homogeneous gold catalysis has developed rapidly and made great progress in recent years, however, the linear structure of Au(I) complexes and the instability of Au(III) organic complexes limit their application in many asymmetric catalytic reactions.Combining gold with organic small molecules as cocatalysts may promote complementary advantages and greatly expand the application scope of asymmetric gold catalysis.Chiral phosphoric acid is a kind of bifunctional organic catalyst with novel structure.Combining chiral phosphoric acids with transition metals can catalyze many new reactions that are difficult to realize with a single catalyst.The asymmetric reactions catalyzed by gold and chiral phosphoric acid are summarized from three aspects, including counter anion directed catalysis, cooperative catalysis and relay catalysis, as well as the latest research progress and development prospects are also discussed.