Photoinduced Difluoromethylation/Cyclization of 2-Aryl Indoles with HCF<sub>2</sub>SO<sub>2</sub>Na
Difluoromethyl compounds are widely found in natural products, bioactive molecule and pharmaceuticals.A visible-light induced difluoromethylation/cyclization of 2-aryl indoles is described to construct indolo[2,1-a]isoquinolin-6(5H)-one derivatives using the inexpensive and easy-to-handle HCF2SO2Na as an HCF2 sources.Diverse difluoromethylated indolo[2,1-a]isoquinolines were readily obtained in moderate to good yields.Mechanistic studies demonstrate that the reaction may involve a radical process.
Authors
- Yucai Tang (ORCID: https://orcid.org/0000-0002-2203-4039)
- Jie Jiang (ORCID: https://orcid.org/0000-0002-0934-7321)
- Yu Chen (ORCID: https://orcid.org/0000-0001-9545-6761)
- Jiale Liu (ORCID: https://orcid.org/0000-0002-8609-580X)
- Jiali Li (ORCID: https://orcid.org/0000-0002-6297-4607)
- Ruohan Pan
Institutions
- Hunan University of Arts and Science (CN)
Publication Details
- Journal
- Chinese Journal of Organic Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.6023/cjoc202409008
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hunan University
- Scientific Research Foundation of Hunan Provincial Education Department