The Effect of Circulating Inflammatory Factors on Sciatic Nerve Injury

坐骨神经痛是坐骨神经或脊髓在经受机械与炎症损伤之后产生的由坐骨神经支配范围疼痛的临床综合征，多表现为剧烈性疼痛和隐匿性疼痛。有时还可伴有其支配范围的无力与麻木异感，不积极的治疗甚至会转变为慢性疼痛，给患者带来极差的情感体验，严重影响患者的生活质量。随着医疗水平的提高和人民生活水平的提高，近几年对坐骨神经痛的研究日益加深，近些年来，炎性因子拮抗剂与受体阻断剂开始应用于临床治疗，本文对近年来坐骨神经痛与炎症因子在临床与实验室的研究进行综述。Sciatica is a clinical syndrome of pain innervated by the sciatic nerve after mechanical and inflammatory damage to the sciatic nerve or spinal cord, which is mostly manifested as severe pain and insidious pain. Sometimes it can be accompanied by weakness and numbness in the scope of its control, and inactive treatment can even turn into chronic pain, which brings extremely poor emotional experience to patients and seriously affects the quality of life of patients. With the improvement of medical standards and the quality of life of the people, research on sciatica has deepened in recent years. In recent years, antagonists of inflammatory factors and receptor blockers have begun to be applied in clinical treatment. This paper reviews the research on sciatica and inflammatory factors in clinical and laboratory settings in recent years.