Maculopathy After Long Term Use and Repeated Suicide Attempt with Topiramate

We present the maculopathy of a 19-year-old female patient diagnosed with idiopathic generalized epilepsy after long term use and 2 suicide attempts with high-dose topiramate. The patient had used topiramate for 2 years before the presentation due to the diagnosis, and after a 2nd suicide attempt using this drug, the patient had vision loss in both eyes and severe maculopathy in the left eye. After discontinuation of topiramate, the patient's maculopathy resolved partially in both eyes. Ophthalmic examination should be kept in mind in such high doses of topiramate, which has been reported to have many ocular adverse effects even in routine clinical use.

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Publication Details

Journal
Turkiye Klinikleri Journal of Ophthalmology
Published
2025-01-01
DOI
https://doi.org/10.5336/ophthal.2024-105506
Primary Topic
Drug-Induced Ocular Toxicity
Type
article
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article

Maculopathy After Long Term Use and Repeated Suicide Attempt with Topiramate

Ebru Çelik, Can Ilker Demir
Turkiye Klinikleri Journal of Ophthalmology
Drug-Induced Ocular Toxicity
article

Maculopathy After Long Term Use and Repeated Suicide Attempt with Topiramate

Ebru Çelik, Can Ilker Demir
article en

Abstract

We present the maculopathy of a 19-year-old female patient diagnosed with idiopathic generalized epilepsy after long term use and 2 suicide attempts with high-dose topiramate. The patient had used topiramate for 2 years before the presentation due to the diagnosis, and after a 2nd suicide attempt using this drug, the patient had vision loss in both eyes and severe maculopathy in the left eye. After discontinuation of topiramate, the patient's maculopathy resolved partially in both eyes. Ophthalmic examination should be kept in mind in such high doses of topiramate, which has been reported to have many ocular adverse effects even in routine clinical use.

Turkiye Klinikleri Journal of OphthalmologyVol. 34(2)
Gender equality
Openalex Percentile: Top 83%
Drug-Induced Ocular Toxicity
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