Potassium Hexamethyldisilazide-Catalyzed Synthesis of 1,3,5-Triaroyl Cyclohexanes

1,3,5-Triaroyl cyclohexane is highly valuable due to its uniqueness of structure.The development of a catalytic and efficient method for the synthesis of 1,3,5-triaroyl cyclohexane is of great value.The cyclotrimerization of chalcones catalyzed by potassium hexamethyldisilazide is described, which effectively produces a series of 1,3,5-triaroyl cyclohexanes in moderate to high yields.A mechanism involving sequential Michael addition catalyzed by silylamide anion is proposed.This method provides a simple, efficient, and atom-economical route for the synthesis of 1,3,5-triaroyl cyclohexanes.