Selenium Mediated Cyclization Reaction of Isonitriles with <i>o</i>-Aminophenols to Synthesize 2-Aminobenzoxazoles

Selenium mediated cyclization reaction of isonitriles with o-aminophenols leading to 2-aminobenzoxazoles has been reported.The present method, which simply utilizes element selenium as promoter and t BuONa as base, provides a green and efficient approach to synthesize various 2-aminobenzoxazoles under mild conditions.This reaction has the advantages of simple operation and metal-free condition.2-Aminobenzothiazole and 2-aminobenzimidazole could also be synthesized through this methodology.