Mandibular Osteosarcoma: Report of Two Cases and Review of Literature

Osteosarcoma is a conjunctive tumor characterized by the elaboration of bony tissue of a malignant aspect. It’s a rare malignant primary tumor of the bone. The localization in the jows is different by its clinical and histopathological features. The evolution is characterized by its gravity due to its aggressive potential, late diagnosis and difficulties met to choose the ideal therapeutic project. Clinically, the symptomatology of this tumor is similar to other bone malignant tumors. Radiologically, it is usually responsable of lytic lesion of the bone, giving sometimes a pathognomonic “sunburst” appearance. The histological diagnosis isn’t always evident. The treatment is essentially surgical, usually associated to a neoadjuvent and adjuvent chemotherapy. Even though medical progress, the prognosis of these tumors still bad and depends on a wide variety of factors, especially the lateness diagnosis and inappropriate treatment. The main aim of this case report was to focus on the importance of early diagnosis of this tumor based on clinical and radiographic examinations, and confirmation by histopathology. Considering the rarity of the disease type and particularly considering the fast progression and aggressiveness of this neoplasm.