Screening of Novel Inhibitors Targeting the Non-ATP-binding Domain of Staphylococcus aureus SecA1
In this thesis, an inhibitor screening strategy based on non-ATP binding structural domains was successfully constructed, which breaks through the limitations of traditional methods to screen candidate molecules with high activity and low risk of potential side effects, and provides an innovative solution to meet the challenge of <i>S. aureus</i> drug resistance.
Authors
- Xu Jia (ORCID: https://orcid.org/0000-0002-1612-1136)
- Xinhe Huang (ORCID: https://orcid.org/0000-0003-4190-0737)
- Sen‐Fang Sui (ORCID: https://orcid.org/0000-0001-5253-2592)
- Hyuk-kyu Seoh
- Yan Liu (ORCID: https://orcid.org/0000-0003-0469-9253)
- Peiyao Liu (ORCID: https://orcid.org/0000-0002-4931-2692)
- Joo‐Heon Hong (ORCID: https://orcid.org/0000-0003-4360-3111)
- Qing Su (ORCID: https://orcid.org/0000-0002-8801-0582)
- Zonglin Wang (ORCID: https://orcid.org/0009-0009-3195-277X)
- Phang-Cheng Tai
Institutions
- Georgia State University (US)
- Chengdu Medical College (CN)
- Southwest Jiaotong University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2025-05-08
- DOI
- https://doi.org/10.2174/0115734064370398250426162503
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00