Therapeutic plasma exchange as a bridge to definitive treatment in severe thyrotoxicosis with propylthiouracil-induced neutropenia

This case highlights the importance of early recognition and management of agranulocytosis induced by antithyroid drugs, particularly in the context of Graves' disease. Therapeutic plasma exchange (TPE) can be an effective bridging therapy for rapid thyroid hormone reduction in thyroid storm, especially when conventional treatments are insufficient or contraindicated. Quick and effective intervention is essential in managing thyroid storm to prevent systemic decompensation, highlighting the importance of a timely and coordinated treatment approach. The role of TPE in managing severe hyperthyroidism underscores the need for flexibility and innovation in critical endocrine emergencies.

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Publication Details

Journal
Endocrinology Diabetes and Metabolism Case Reports
Published
2025-04-01
DOI
https://doi.org/10.1530/edm-24-0150
Citations
1
Primary Topic
Blood disorders and treatments
Type
article
Field-Weighted Citation Impact
1.82
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article

Therapeutic plasma exchange as a bridge to definitive treatment in severe thyrotoxicosis with propylthiouracil-induced neutropenia

Sanja Medenica, Vladimir Prelević, Nenad Laketić, Filip Tomović et al.
1 citations
Endocrinology Diabetes and Metabolism Case Reports
Blood disorders and treatments
1.82
article

Therapeutic plasma exchange as a bridge to definitive treatment in severe thyrotoxicosis with propylthiouracil-induced neutropenia

Sanja Medenica, Vladimir Prelević, Nenad Laketić, Filip Tomović, Pinaki Dutta, Mirjana Stojković, Vinitaa Jha, Nataša Bajčeta
article en
1 citations

Abstract

This case highlights the importance of early recognition and management of agranulocytosis induced by antithyroid drugs, particularly in the context of Graves' disease. Therapeutic plasma exchange (TPE) can be an effective bridging therapy for rapid thyroid hormone reduction in thyroid storm, especially when conventional treatments are insufficient or contraindicated. Quick and effective intervention is essential in managing thyroid storm to prevent systemic decompensation, highlighting the importance of a timely and coordinated treatment approach. The role of TPE in managing severe hyperthyroidism underscores the need for flexibility and innovation in critical endocrine emergencies.

Endocrinology Diabetes and Metabolism Case ReportsVol. 2025(2)
University of Belgrade (RS), Post Graduate Institute of Medical Education and Research (IN), University of Montenegro (ME)
Good health and well-being
Openalex Percentile: Top 16%
Blood disorders and treatments
1.82
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