Therapeutic plasma exchange as a bridge to definitive treatment in severe thyrotoxicosis with propylthiouracil-induced neutropenia
This case highlights the importance of early recognition and management of agranulocytosis induced by antithyroid drugs, particularly in the context of Graves' disease. Therapeutic plasma exchange (TPE) can be an effective bridging therapy for rapid thyroid hormone reduction in thyroid storm, especially when conventional treatments are insufficient or contraindicated. Quick and effective intervention is essential in managing thyroid storm to prevent systemic decompensation, highlighting the importance of a timely and coordinated treatment approach. The role of TPE in managing severe hyperthyroidism underscores the need for flexibility and innovation in critical endocrine emergencies.
Authors
- Sanja Medenica (ORCID: https://orcid.org/0000-0002-6241-3033)
- Vladimir Prelević (ORCID: https://orcid.org/0000-0002-5219-5116)
- Nenad Laketić
- Filip Tomović
- Pinaki Dutta (ORCID: https://orcid.org/0000-0001-5415-1611)
- Mirjana Stojković (ORCID: https://orcid.org/0000-0003-0390-3726)
- Vinitaa Jha (ORCID: https://orcid.org/0000-0001-7247-5492)
- Nataša Bajčeta
Institutions
- University of Belgrade (RS)
- Post Graduate Institute of Medical Education and Research (IN)
- University of Montenegro (ME)
Publication Details
- Journal
- Endocrinology Diabetes and Metabolism Case Reports
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1530/edm-24-0150
- Citations
- 1
- Primary Topic
- Blood disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.82