Clinical case of locally advanced renal cell carcinoma with an inferior vena cava tumor thrombus treated with VEGFR-TKI/IO combination pembrolizumab + lenvatinib
The article presents a clinical case of treatment of a young man with locally advanced renal cell carcinoma with an inferior vena cava tumor thrombus above the diaphragm. Due to non-standard neoadjuvant approach of using modern tyrosine kinase inhibitors of VEGFR and immunotherapy (VEGFR-TKI/IO) combination pembrolizumab + lenvatinib, thoracotomy was avoided and complete pathological regression of the tumor was achieved. Various studies on neoadjuvant therapy of kidney cancer including in patients with tumor thrombus are discussed, and the prospects for introducing this approach into clinical practice are described.
Authors
- М. I. Shkolnik (ORCID: https://orcid.org/0000-0003-0589-7999)
- И. О. Руткин (ORCID: https://orcid.org/0000-0002-9018-0433)
- Р. В. Орлова (ORCID: https://orcid.org/0000-0003-4447-9458)
- M. I. Gluzman (ORCID: https://orcid.org/0000-0002-8965-8364)
- О. А. Богомолов (ORCID: https://orcid.org/0000-0002-5860-9076)
- Kozlov Av (ORCID: https://orcid.org/0000-0002-6878-6762)
- С. А. Сидорова (ORCID: https://orcid.org/0000-0002-6298-9809)
Institutions
- St Petersburg University (RU)
- Ministry of Health of the Russian Federation (RU)
- City Clinical Oncology Center (RU)
- Russian Scientific Center of Radiology and Surgical Technologies (RU)
- State Healthcare Institution "Regional Clinical Oncological Dispensary" (RU)
Publication Details
- Journal
- Cancer Urology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.17650/1726-9776-2025-21-1-92-99
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00