Altered GIP/GLP-1 Secretion Ratio is Associated With Impaired β Cell Function in Humans
Our findings demonstrate that, despite similar GIP and GLP-1 secretion, the GIP/GLP-1 SR declines as glucose tolerance deteriorates, reflecting an imbalance in incretin dynamics rather than absolute hormone secretion. This imbalance may indicate early β cell dysfunction and chronic incretin resistance.
Authors
- Giuseppe Quero (ORCID: https://orcid.org/0000-0002-0001-9479)
- Sara Sofia De Lucia (ORCID: https://orcid.org/0009-0005-3644-8063)
- Enrico Celestino Nista
- Gea Ciccarelli (ORCID: https://orcid.org/0009-0001-3621-6298)
- Bolette Hartmann (ORCID: https://orcid.org/0000-0001-8509-2036)
- Gianfranco Di Giuseppe (ORCID: https://orcid.org/0000-0003-4506-5193)
- Laura Soldovieri (ORCID: https://orcid.org/0009-0001-3315-0406)
- Michela Brunetti (ORCID: https://orcid.org/0009-0008-0139-4749)
- Teresa Mezza (ORCID: https://orcid.org/0000-0001-5407-9576)
- Francesca Cinti (ORCID: https://orcid.org/0000-0001-5170-7055)
- Andrea Giaccari (ORCID: https://orcid.org/0000-0002-7462-7792)
- Jens Juul Holst (ORCID: https://orcid.org/0000-0001-6853-3805)
- Alfredo Pontecorvi (ORCID: https://orcid.org/0000-0003-0570-6865)
- Antonio Gasbarrini (ORCID: https://orcid.org/0000-0003-4863-6924)
- Andrea Mari (ORCID: https://orcid.org/0000-0002-1436-5591)
- Lorenzo Carciero
- Sergio Alfieri (ORCID: https://orcid.org/0000-0002-8057-0788)
- Giulia Gliozzo (ORCID: https://orcid.org/0009-0002-1065-6030)
Institutions
- University of Copenhagen (DK)
- National Academies of Sciences, Engineering, and Medicine (US)
- Novo Nordisk Foundation (DK)
- Agostino Gemelli University Polyclinic (IT)
- University of the Sacred Heart (JP)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1210/clinem/dgaf210
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- European Foundation for the Study of Diabetes
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Università Cattolica del Sacro Cuore