Altered GIP/GLP-1 Secretion Ratio is Associated With Impaired β Cell Function in Humans

Our findings demonstrate that, despite similar GIP and GLP-1 secretion, the GIP/GLP-1 SR declines as glucose tolerance deteriorates, reflecting an imbalance in incretin dynamics rather than absolute hormone secretion. This imbalance may indicate early β cell dysfunction and chronic incretin resistance.

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Publication Details

Journal
The Journal of Clinical Endocrinology & Metabolism
Published
2025-05-09
DOI
https://doi.org/10.1210/clinem/dgaf210
Citations
3
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
3.88

Funders

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article

Altered GIP/GLP-1 Secretion Ratio is Associated With Impaired β Cell Function in Humans

Giuseppe Quero, Sara Sofia De Lucia, Enrico Celestino Nista, Gea Ciccarelli et al.
3 citations
The Journal of Clinical Endocrinology & Metabolism
Diabetes Treatment and Management
3.88
article

Altered GIP/GLP-1 Secretion Ratio is Associated With Impaired β Cell Function in Humans

Giuseppe Quero, Sara Sofia De Lucia, Enrico Celestino Nista, Gea Ciccarelli, Bolette Hartmann, Gianfranco Di Giuseppe, Laura Soldovieri, Michela Brunetti, Teresa Mezza, Francesca Cinti, Andrea Giaccari, Jens Juul Holst, Alfredo Pontecorvi, Antonio Gasbarrini, Andrea Mari, Lorenzo Carciero, Sergio Alfieri, Giulia Gliozzo
article en
3 citations

Abstract

Our findings demonstrate that, despite similar GIP and GLP-1 secretion, the GIP/GLP-1 SR declines as glucose tolerance deteriorates, reflecting an imbalance in incretin dynamics rather than absolute hormone secretion. This imbalance may indicate early β cell dysfunction and chronic incretin resistance.

The Journal of Clinical Endocrinology & MetabolismVol. 111(1)
University of Copenhagen (DK), National Academies of Sciences, Engineering, and Medicine (US), Novo Nordisk Foundation (DK), Agostino Gemelli University Polyclinic (IT), University of the Sacred Heart (JP)
European Foundation for the Study of Diabetes, Ministero della Salute, Ministero dell’Istruzione, dell’Università e della Ricerca, Università Cattolica del Sacro Cuore
Good health and well-being
Openalex Percentile: Top 7%
Diabetes Treatment and Management
3.88
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