PHARMACOGNOSTIC EVALUATION OF NATURAL ANTIOXIDANTS: IMPLICATIONS FOR AGING AND AGE-RELATED DISORDERS

Oxidative stress, among other things, contributes to aging, which is an ordinary though multifactorial process in the cells of the body.Oxidative stress, which is the disturbance with an equilibrium between body-generated ROS and antioxidants, is the main causative agent of aging and age-related diseases including cancer, neurodegenerative diseases, cardiovascular illnesses, and diabetes.Polyphenol antioxidants in food and medicinal plants have come to limelight as weapons against oxidative stress in the recent past.Carotenoids, flavonoids, polyphenols, and other words are some of the bioactive compounds of foods, beverages, and herbs that perform several tasks that include scavenging of free radicals, alteration of the cellular signal transduction pathways, return of cellular oxidant balance, and boosting of the cells' automatic protective mechanisms.This review includes analysis of the plant origin, chemical constitutions and the healing and antagonism possessed by natural antioxidants and their pharmacognostic account.In an effort to have uniformity in analyzing these chemicals, newer techniques such as HPLC spectroscopy and chromatography are valued.The versatility of antioxidants in therapeutic applications is well illustrated in such examples as quercetien, resveratrol, curcumin.They highlighted that clinical research of the effects of geroprotectors is presented as a connection between pharmacognostic research and clinical practice, which can show their ability to fight agerelated diseases and slow down aging.Innovative strategies to tackle problems such as unequal effectiveness and poor solubility are on the agenda, including features such as nanotechnology platform, ethosomal forms and bioenhancers.Only when entailing traditional pharmacognostic practices and advanced modern technology discoveries is the comprehensive recuperative significance of natural antioxidants best realized, as the present article underlines.With an aim to build a healthier and stronger populace for aging, this review attempts to encapsulate existing evidence base and forward-looking perspectives.It is made for the purpose of advancing knowledge and encourage future work in the area of anti-aging and diseases.