U-Net V2: Rethinking the Skip Connections of U-Net for Medical Image Segmentation

In this paper, we introduce U-Net v2, a new robust and efficient U-Net variant for medical image segmentation. It aims to augment the infusion of semantic information into low-level features while simultaneously refining high-level features with finer details. For an input image, we begin by extracting multilevel features with a deep neural network encoder. Next, we enhance the feature map of each level by infusing semantic information from higher-level features and integrating finer details from lower-level features through Hadamard product. Our novel skip connections empower features of all the levels with enriched semantic characteristics and intricate details. The improved features are subsequently transmitted to the decoder for further processing and segmentation. Our method can be seamlessly integrated into any Encoder-Decoder network. We evaluate our method on several public medical image segmentation datasets for skin lesion segmentation and polyp segmentation, and the experimental results demonstrate the segmentation accuracy of our new method over state-of-the-art methods, while preserving memory and computational efficiency. Code is available at: https://github.com/yaoppeng/U-Net_v2.

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Publication Details

Published
2025-04-14
DOI
https://doi.org/10.1109/isbi60581.2025.10980742
Citations
70
Primary Topic
COVID-19 diagnosis using AI
Type
article
Field-Weighted Citation Impact
93.85
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article

U-Net V2: Rethinking the Skip Connections of U-Net for Medical Image Segmentation

Yaopeng Peng, Milan Sonka, Danny Z. Chen
70 citations
COVID-19 diagnosis using AI
93.85
article

U-Net V2: Rethinking the Skip Connections of U-Net for Medical Image Segmentation

Yaopeng Peng, Milan Sonka, Danny Z. Chen
article en
70 citations

Abstract

In this paper, we introduce U-Net v2, a new robust and efficient U-Net variant for medical image segmentation. It aims to augment the infusion of semantic information into low-level features while simultaneously refining high-level features with finer details. For an input image, we begin by extracting multilevel features with a deep neural network encoder. Next, we enhance the feature map of each level by infusing semantic information from higher-level features and integrating finer details from lower-level features through Hadamard product. Our novel skip connections empower features of all the levels with enriched semantic characteristics and intricate details. The improved features are subsequently transmitted to the decoder for further processing and segmentation. Our method can be seamlessly integrated into any Encoder-Decoder network. We evaluate our method on several public medical image segmentation datasets for skin lesion segmentation and polyp segmentation, and the experimental results demonstrate the segmentation accuracy of our new method over state-of-the-art methods, while preserving memory and computational efficiency. Code is available at: https://github.com/yaoppeng/U-Net_v2.

University of Notre Dame (US), University of Iowa (US)
Openalex Percentile: Top 0%
COVID-19 diagnosis using AI
93.85
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