Modeling and Analysis of a Microfluidic Biosensor for Selective Cell Control in Lab-on-Chip Applications

Biological cell analysis, detection, separation from blood samples is an important task in evaluation and information extraction in health care disease diagnostics. In such sensor the cells are required to be controlled and migrated in particular channel area or cell analysis zone of a lab-on-chip device. Dielectrophoresis based microfluidic lab-on-chip devices are well established for manipulating cell movement which is suitable for detection and analysis. In this research, a microfluidic Biosensor for biological cell trajectory control is presented for trajectory control of platelets and red blood cells by optimizing the voltage applied on electrodes. Cell trajectory control is performed based on cell diameter and cell polarization effect on cells. Result have shown that motion of both platelets and red blood cells can be selectively controlled using voltages on electrodes with specific scheme having in range -4V to 4V such that cells can be captured in desired outlet.