Realistically Poseable Mouse Model for Assessing Exposures to Magnetic Field in the Intermediate Frequency Band

Recently, a mouse model was used to quantify electromagnetic (EM) dosimetry in an investigation of the biological effects of an EM field in the intermediate-frequency band (300 Hz to 10 MHz). However, it did not reflect the realistic postures observed during exposure experiments; thus, the data obtained were not accurate. In this study, a poseable mouse mesh model was developed using photogrammetry techniques; its pose was changed to mimic ten realistic postures observed during exposure experiments. The mouse model was composed of ten different tissues and organs: the eyes, brain, skull, bone, liver, lungs, heart, spleen, glands, and skin. The dosimetry evaluation was performed on the mouse model under a uniformly applied magnetic field intensity. The reliability and accuracy of the EM solver used in the evaluation were validated by performing a dosimetry evaluation on a homogeneous sphere and ellipsoid exposed to a uniform magnetic field; the results were compared with those obtained by the analytical method. Dosimetric quantification was performed using several metrics. The metrics included the whole-body average (<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</i><sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">WBA</sup>), 99<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> percentile (<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</i><sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">99</sup>), 99.9<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> percentile (<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</i><sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">99</sup>.9), and maximum (Emax) values of the induced electric field intensity inside the mouse body. For an applied magnetic field density of 1 mT at 100 kHz, the <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</i><sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">WBA</sup>, <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</i><sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">99</sup>, <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</i><sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">99</sup>.9, and Emax values for the poseable mouse in the standing, upright, and curled-up positions were derived and discussed. The developed poseable mouse model potentially provides accurate exposure data for animal experiments under freely roaming conditions.