Evaluation of Uric Acid Level in Albino Rabbits Treated with Ivy Leaves Extract

Objective: Evaluate the effect of dried Ivy leaves extract on blood uric acid in Albino Rabbits. Study Design: Experimental study Place and Duration of Study: This study was conducted at the Pharmacology Research Department of University of Karachi, duration of study was 2 months from 20 June 2019 to 19 Aug 2019. Methods: Dried Ivy leaves extract was given to Rabbits and they were consigned in 2 groups, group A was given normal saline and it was control group while group B, treatment group, was given Ivy leaves extract. Blood samples were drawn from control and treated groups and Uric acids levels were tested on day 7, 15 and 30 respectively. Results: As it is evident from results that animals treated with Ivy leaves extract showed significant reduction in normal serum uric acid level compared to control group. Mean level of Uric Acid Level mg/dl at Day 7 in groups 1 and 2 was 5.10±0.51 and 4.78±0.27, at day 30 in group 1 and 2 was 4.98±0.34 and 3.76±0.32 and at day 60 in groups 1 and 2 was 5.06±0.48 and 3.46±0.48 it shows significant difference among the groups (p<0.001). Conclusion: Current study showed that some acidic compounds and amino acids present in Ivy leaves extract can impair reabsorption of uric acid which ultimately increases its elimination so uric acid concentration decreased significantly in treated groups given Ivy leaves extract.