Comprehensive αβ T‐Cell Receptor Repertoire Analysis Reveals a Unique CD8+ TCR Landscape in DOCK8‐Deficient Patients
Our study represents the most comprehensive immune repertoire analysis in DOCK8 deficiency. The identification of a significantly restricted αβ TCR repertoire, along with the detection of potentially autoreactive clones, highlights the crucial role of immune repertoire profiling in elucidating the pathogenesis of DOCK8 deficiency.
Authors
- Tuğba Arıkoğlu (ORCID: https://orcid.org/0000-0003-3340-571X)
- Gülşah Merve Kılınç (ORCID: https://orcid.org/0000-0002-2024-3910)
- Safa Barış (ORCID: https://orcid.org/0000-0002-4730-9422)
- Betül Karaatmaca (ORCID: https://orcid.org/0000-0002-8383-6350)
- Nicholas I. Warnock (ORCID: https://orcid.org/0000-0003-3422-3184)
- Sule Haskologlu
- Elif Karakoç-Aydıner (ORCID: https://orcid.org/0000-0003-4150-5200)
- Figen Doğu (ORCID: https://orcid.org/0000-0002-7869-4941)
- Gökhan Cildir (ORCID: https://orcid.org/0000-0001-7457-9164)
- Baran Erman (ORCID: https://orcid.org/0000-0001-9398-8465)
- Aylin KONT ÖZHAN (ORCID: https://orcid.org/0000-0003-0486-0422)
- Saliha Esenboğa (ORCID: https://orcid.org/0000-0003-0562-9863)
- Chung Hoow Kok (ORCID: https://orcid.org/0000-0002-3181-7852)
- Deniz Çağdaş (ORCID: https://orcid.org/0000-0003-2213-4627)
- Asena Pınar Sefer (ORCID: https://orcid.org/0000-0003-2667-0291)
- Candan İslamoğlu (ORCID: https://orcid.org/0000-0002-8177-9348)
- Kübra Baskın (ORCID: https://orcid.org/0000-0002-4294-7492)
- Çiğdem Aydoğmuş (ORCID: https://orcid.org/0000-0002-6036-7694)
- Ahmet Özen
- Sevgi Bilgiç Eltan (ORCID: https://orcid.org/0000-0003-0561-3343)
- Ümran Aba (ORCID: https://orcid.org/0000-0001-9458-3953)
- Canberk İpşir (ORCID: https://orcid.org/0000-0003-0726-5004)
- Ayşe Metìn (ORCID: https://orcid.org/0000-0002-0731-5799)
- Sidem Tekeoglu (ORCID: https://orcid.org/0000-0002-5748-2659)
- Aydan Ikincioğullari
- Ceren Bozkurt (ORCID: https://orcid.org/0000-0003-0009-5655)
- Rahmi Kutay Erdogan
Institutions
- South Australia Pathology (AU)
- Recep Tayyip Erdoğan University (TR)
- University of Health Science (KH)
- University of South Australia (AU)
- Hacettepe University Hospital (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Centre for Cancer Biology (AU)
- Mersin Üniversitesi (TR)
- The University of Adelaide (AU)
- Hacettepe University (TR)
- Marmara University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Allergy
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1111/all.16580
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hospital Research Foundation
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Hacettepe Üniversitesi
- Marmara Üniversitesi