<i>ABCB1, SLC22A1, COMT,</i> and <i>OPRM1</i> genotypes: Study of their influence on plasma methadone levels and clinical response to methadone maintenance treatment in opioid use disorder
This study found no evidence to support the use of genotyping for polymorphisms in the ABCB1, SLC22A1, COMT, and OPRM1 genes in a clinical setting for the management of MMT in OUD.
Authors
- Abd El Kader Ait Tayeb (ORCID: https://orcid.org/0000-0001-6432-1098)
- Caroline Victorri‐Vigneau (ORCID: https://orcid.org/0000-0002-3745-2532)
- Edouard‐Jules Laforgue (ORCID: https://orcid.org/0000-0002-7400-1212)
- Benoît Schreck (ORCID: https://orcid.org/0000-0002-6141-9986)
- Jean-Benoît Hardouin (ORCID: https://orcid.org/0000-0001-8664-623X)
- Céline Verstuyft (ORCID: https://orcid.org/0000-0002-8534-224X)
- Juliette Leboucher (ORCID: https://orcid.org/0000-0002-4586-5011)
- Marie Grall‐Bronnec (ORCID: https://orcid.org/0000-0003-0722-7243)
Institutions
- Université de Tours (FR)
- Inserm (FR)
- Université Paris-Saclay (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Centre d'Investigation Clinique de Nantes (FR)
- Bicêtre Hospital (FR)
- methodS in Patient-centered outcomes and HEalth ResEarch
- Nantes Université (FR)
Publication Details
- Journal
- Fundamental and Clinical Pharmacology
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1111/fcp.70013
- Citations
- 1
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Université Paris 13
- Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives