ASSESSMENT OF ERYTHROPOIETIN AND RENAL BIOMARKERS OF DIABETICS WITH COMPLICATIONS IN BENIN CITY, EDO STATE

Chronic diabetes mellitus is a metabolic disorder characterized by persistent hyperglycemia and associated complications. Assessing erythropoietin (EPO) levels and glycated hemoglobin (HbA1c) levels in diabetic patients can provide valuable insights into the management and progression of the disease. This study aimed to assess the levels of erythropoietin and renal parameters in patients with complications of diabetes mellitus and evaluate the clinical implications of these assessments. A total of eighty-one consenting participants including 21 patients presenting complications of diabetes mellitus, 30 diabetic patients without any complications, and 30 heathy control persons without history of diabetes mellitus. Erythropoietin level was measured using enzyme-linked immunosorbent assay (ELISA), and HbA1c levels were also determined through modified enzymatic reaction, packed cell volume, haemoglobin, urea and creatinine values were determined using standard methods. Demographic and clinical data, including age, gender, diabetes duration, and medication history, were collected via questionnaires. Statistical analysis was performed to determine the correlation between EPO levels and HbA1c levels. Values obtained in this study was presented as mean ± standard deviation (levels of significance were accepted at p<0.001). In this study, high HbA1c levels among diabetic patients with complications were associated with a diet rich in protein and carbohydrates. Additionally, the increased erythropoietin levels were attributed to the absence of nephropathy, a condition typically linked to lower erythropoietin levels, in these patients. Further research is warranted to explore the clinical implications of these assessments in predicting diabetes complications and guiding therapeutic interventions.