Oncolytic reovirus enhances the effect of CEA immunotherapy when combined with PD1-PDL1 inhibitor in a colorectal cancer model
The combination of tumor vaccines with oncolytic viruses significantly improves treatment efficacy. Furthermore, inhibiting the PD-1/PD-L1 interaction during vaccination and also with virotherapy enhances immunovirotherapy by reducing immunosuppressive effects and stimulating the immune system, leading to improved therapeutic outcomes.
Authors
- Nazila Hajiahmadi
- Mohammad Farahmand (ORCID: https://orcid.org/0000-0002-9648-9298)
- Atefeh Yari (ORCID: https://orcid.org/0000-0002-4489-5438)
- Taravat Bamdad (ORCID: https://orcid.org/0000-0003-3620-0701)
- Seyed Younes Hosseini (ORCID: https://orcid.org/0000-0002-5881-6796)
- Sanaz Asiyabi (ORCID: https://orcid.org/0000-0002-0423-3181)
Institutions
- Tarbiat Modares University (IR)
Publication Details
- Journal
- Immunotherapy
- Published
- 2025-04-13
- DOI
- https://doi.org/10.1080/1750743x.2025.2501926
- Citations
- 4
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.93
Funders
- National Institute for Medical Research Development