Autologous Fat Grafting for Facial Volume Restoration in Parry-Romberg Syndrome: A Retrospective Study of 7 Cases

Background: Parry-Romberg syndrome (PRS) is a rare craniofacial disorder characterized by progressive hemifacial atrophy. While autologous fat grafting (AFG) has emerged as a promising treatment, long-term volumetric outcomes remain poorly characterized. Methods: This retrospective study analyzed 7 PRS patients (6F:1M; mean age 22±7.2 years) treated between 2021-2024. Fat was harvested via Coleman technique, processed by centrifugation (3000 rpm × 3 min), and injected in three anatomical layers Results: Mean volume retention was 62.3±8.7% at 12 months (p<0.01). Adipocyte viability correlated strongly with centrifugation force (83.2% at 3000 rpm vs 68.1% at 1200 rpm, p=0.003). FACE-Q scores improved from 32.1 to 78.4 (p<0.001). Conclusion: AFG provides durable restoration in PRS when performed with optimized processing parameters. This study establishes centrifugation at 3000 rpm as the gold standard for adipocyte preservation.