SI-PPC-induced modulation of heparin/heparanase binding affinity: a steered molecular dynamics approach
We report a steered molecular dynamics (SMD) investigation into how substitution-inert polynuclear platinum complexes (SI-PPCs) influence the binding affinity between heparan sulphate (HS) and the enzyme heparanase.
Authors
- Luiz Antônio S. Costa (ORCID: https://orcid.org/0000-0002-8544-2910)
- Nicholas P. Farrell (ORCID: https://orcid.org/0000-0001-7160-7182)
- Frederico Henrique do Carmo Ferreira
Institutions
- Universidade Federal de Juiz de Fora (BR)
- Virginia Commonwealth University (US)
Publication Details
- Journal
- Inorganic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qi00461f
- Citations
- 1
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Commonwealth Health Research Board
- Conselho Nacional de Desenvolvimento Científico e Tecnológico