Efficacy of Carbopol as an Adjuvant for Inactivated Rift Valley Fever Vaccine

The purpose of the current study was to examine the immune response of sheep given the Rift Valley Fever virus vaccination adjuvanted with Carbopol®. Fifteen sheep were divided into three groups of five each. The first group received the ALOH adjuvanted inactivated RVF vaccination. The second group received the carbopol adjuvanted inactivated RVF vaccination. In the third group, no immunizations were administered as a control. In order to evaluate the Cellular immune response and the humeral immune response, the generated vaccines were evaluated by measuring the levels of interleukin, interferon and antibody levels using the enzyme linked immunosorbant assay (ELISA) and serum neutralization test (SNT). The efficacy of the vaccines was assessed using the challenge test in mice. The findings showed that the Carbopol® Adjuvanted inactivated RVF vaccine generated a potent immune response better than the traditionally produced ALOH adjuvanted vaccine.