The two cut‐offs approach for plasma p‐tau217 in detecting Alzheimer's disease in subjective cognitive decline and mild cognitive impairment
Plasma phosphorylated tau (p-tau)217 was highly accurate in detecting Alzheimer's disease (AD) pathology.The two cut-offs approach increased plasma p-tau217 accuracy for AD diagnosis.Even when measured with immunoassay, p-tau217 is a good biomarker for AD diagnosis.Transition of p-tau217 from research setting to clinical practice seems feasible.
Authors
- Federico Emanuele Pozzi (ORCID: https://orcid.org/0000-0003-2982-9165)
- Giulia Giacomucci (ORCID: https://orcid.org/0000-0002-8711-331X)
- Salvatore Mazzeo (ORCID: https://orcid.org/0000-0001-5985-5060)
- Sonia Padiglioni
- Benedetta Nacmias (ORCID: https://orcid.org/0000-0001-9338-9040)
- Valentina Moschini
- Silvia Bagnoli (ORCID: https://orcid.org/0000-0002-4373-6611)
- Valentina Berti (ORCID: https://orcid.org/0000-0001-9947-6559)
- Carmen Morinelli
- Assunta Ingannato (ORCID: https://orcid.org/0000-0003-4955-0321)
- Valentina Bessi
- Chiara Crucitti
- Sandro Sorbi
- Elisa Marcantelli
Institutions
- Vita-Salute San Raffaele University (IT)
- IRCCS Policlinico San Donato (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Don Carlo Gnocchi Foundation (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Agenzia Regionale di Sanità della Toscana (IT)
- Regione Toscana
- University of Florence (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/dad2.70116
- Citations
- 5
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- European Commission