Treatment features of recurrent vulvovaginal candidiasis on the basis of papillomavirus infection

Aim - evaluation of effectiveness of vaginal suppositories containing boric acid and centella asiatica (Centella asiatica) for treatment in recurrent vulvovaginal candidiasis (RVVC) on the basis of papillomavirus infection. Materials and methods. The effectiveness of vaginal suppositories containing boric acid and centella asiatica (Centella asiatica) in treatment of RVVC in patients with papillomavirus infection was carried out. The study included 38 patients of the "Nova Medical" medical center (Vasylkiv) with RVVC, who had 3-5 repeated VVC episodes during the last year, on the basis of papillomavirus infection (confirmed by PCR). All patients received vaginal suppositories in the treatment regimen during 14 days. Statistical analysis was performed using the SPSS Statistics software (Statistica 6.0). Differences at p<0.05 are considered statistically significant. Results. All patients before treatment had inflammatory changes of the vaginal and cervical epithelium with the confirmed candidal nature: minor reaction - 28.9%, moderate - 63.2% and severe - 7.9%. The data obtained after using vaginal suppositories containing boric acid and centella asiatica (Centella asiatica) demonstrate a significant reduction in hyperemia of the vulvovaginal zone - 84.2% and -10.5% - slight hyperemia after treatment and the disappearance of microcracks (p<0.05). The colposcopic features indicates a significant decrease in the severity of the inflammatory process of the vagina and exocervix - 86.8% (p<0.05). Microscopic examination indicates 100% presence of candidal infection before treatment versus 13.2% after treatment. (p<0.05). Conclusions. Vulvovaginal candidiasis occurs in 59.4% of patients with papillomavirus infection. Combination of boric acid and centella asiatica (Centella asiatica) shows significant effectiveness of treatment RVVC. Clinical recovery was a total of 89.4%. Microbiological recovery was 86.8%. (p<0.05). The occurrence of repeated relapses after treatment did not have statistical significance, 13.2% of asymptomatic carriers of candidal infection required an extension of course up to 8 weeks. The study was carried out in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Сommittee on bioethics and deontology of these institutions. Informed consent of the patients was obtained for the study. No conflict of interests was declared by the authors.