The safety and effectiveness of non-hormonal treatment in menopausal disorders

The use of non-hormonal therapy for the manifestations of CR will significantly improve the quality of life of women in the menopausal period due to its effectiveness and absence of side effects. It will also solve the issue of correcting menopausal disorders in women in whom menopausal hormone therapy is contraindicated. Aim - to assess the safety and effectiveness of the herbal preparation Menoel® PLUS (EstroG-100®) in the treatment of menopausal disorders. Materials and methods. The study involved 40 women of menopausal age with climacteric disorders. After confirmation of climacteric disorders in patients, they were distributed as follows: the Group I - 20 participants received MHT; the Group II included 20 women who received: the Subgroup IIA - 10 women: MHT and Menoel® PLUS; the Subgroup IIB - 10 women who had contraindications to MHT received Menoel® PLUS as monotherapy. Results. Over 6 months of therapy, the indicators of psychological and somato-vegetative manifestations of the MRS scale significantly decreased in women using menopausal hormone therapy and Menoel® PLUS. The assessment of the mental tension index on the PSM-25 scale demonstrated that during 6 months of treatment, a clinically significant effect was obtained in the both groups, but in the Subgroup IIA it was more significant - already in 3 months the stress level decreased from 169.4±8.6 to 121.6±8.6 points, and in 6 months to 102±8.3 (p<0.05). Conclusions. Non-hormonal drugs (Menoel® plus) can be used in combination with MHT for the treatment of climacteric disorders and are the only option for women with contraindications to estrogen or progestogen therapy. The study was carried out in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Committee on bioethics and deontology of these institutions. The informed consent of the children's parents was obtained for the research. No conflict of interests was declared by the author.