Course features of IgA-associated vasculitis in children at the present stage

IgA-associated vasculitis belongs to primary systemic vasculitides, and its frequency makes 3-27 cases per 100,000 children. Aim - to establish the course features of IgA-associated vasculitis in children. Materials and methods. 50 medical records of hospitalized patients who were treated at the Communal Non-Profit Enterprise "Ivano-Frankivsk Regional Children's Clinical Hospital of the Ivano-Frankivsk Regional Council" for IgA-associated vasculitis between 2015 and 2019 were analyzed. And 57 patients, aged 3 to 18 years, who were undergoing inpatient treatment between 2019 and 2024 were examined. The Group I includes 71 (66.4%) patients with IgA-vasculitis, associated with acute respiratory diseases. The Group II includes 36 (33.6%) patients with manifestation of illness after allergic reactions. Results. Course features of vasculitis in patients of the Group I are as follows: age from 4 to 7 years (40.0% and 10.0%), duration of the disease before admission to the hospital - 14.0±2.5; male gender (71.0% and 29.0%). In patients of the Group I, the most common clinical form is articular (45.0%), while in the patients of the Group II, cutaneous (61.0%) form prevails accordingly. Kidney damage occurs in 10.0% patients of the Group I. Conclusions. The prevalence of IgA-associated vasculitis in the Ivano-Frankivsk region coincides with similar data for Ukraine (8.0-12.0 cases per 100,000 children). The most meaningful signs in patients of the Group I includes: age, the duration of the illness before admission to the hospital, and gender features. The most common clinical form in the Group I patients is articular (45.0%), while in patients of the Group II - cutaneous (61.0%). The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.