18F-FAPI PET/CT for Early Detection and Severity Assessment of Intestinal Fibrosis in a Mouse Model
As Crohn's disease (CD) with intestinal fibrosis progresses, 18F-FAPI uptake is high in the early stages and then gradually decreases. Activated fibroblasts appear more frequently in the early stages of intestinal fibrosis indicates that 18F-FAPI PET has a great potential for early identification of intestinal fibrosis and provides new insights into treatment decision-making in CD patients.
Authors
- Jianghua Ran
- Weicheng Zhou (ORCID: https://orcid.org/0000-0002-5140-2689)
- Dianjianyi Sun (ORCID: https://orcid.org/0000-0003-3651-6693)
- X. Chen (ORCID: https://orcid.org/0000-0002-8647-0614)
- Chaoqun Lv
- Xinyue Hu (ORCID: https://orcid.org/0000-0002-2508-121X)
- Hongqing Li (ORCID: https://orcid.org/0000-0003-0658-6295)
- Lei Chen (ORCID: https://orcid.org/0000-0002-1760-2046)
- Kaijun Liu (ORCID: https://orcid.org/0000-0003-0027-9278)
- Dongfeng Chen
- Yi Tang
- Daoxi Hu
- Jie You (ORCID: https://orcid.org/0000-0003-3735-0592)
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
- Southwest Hospital (CN)
- Tibet Autonomous Region People's Hospital (CN)
- Dali University (CN)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1093/ibd/izaf086
- Citations
- 4
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Natural Science Foundation of Chongqing