Impact of intercellular adhesion molecule 1‐positive dental pulp stem cells in deep caries progression
During deep caries progression, TNF-α drives the transformation of DPSCs into inflammatory ICAM1<sup>+</sup> DPSCs. This subcluster exhibits impaired odontogenic differentiation capacity, secretes proinflammatory cytokines and chemokines, and enhances macrophage inflammatory activity, contributing to the advancement of deep caries lesions.
Authors
- Sun J
- Xiatong Zhang
- Wenzhi Wu (ORCID: https://orcid.org/0009-0001-6912-1623)
- Jingchen Zhang (ORCID: https://orcid.org/0000-0003-3132-916X)
- Zhuo Chen (ORCID: https://orcid.org/0000-0001-8247-7387)
- Yi Zhang (ORCID: https://orcid.org/0000-0002-5282-5771)
- Yi Chen (ORCID: https://orcid.org/0000-0002-3644-8718)
- Yulian Zhang (ORCID: https://orcid.org/0009-0009-6085-858X)
Institutions
- Stomatology Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1111/iej.14248
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China