PGC-1α agonist ZLN005 ameliorates OVA-induced asthma in BALB/c mice through modulating the NF-κB-p65/NLRP3 pathway.
PGC-1α agonist (ZLN005) regulated lung inflammation in asthmatic mice by inhibiting the NF-κB-p65/NLRP3 signaling pathway, supporting that ZLN005 may be a candidate for future asthma treatment.
Authors
- Rui Fang (ORCID: https://orcid.org/0000-0001-6075-9201)
- Liqi Yang (ORCID: https://orcid.org/0000-0002-7801-9882)
- Ping Chen (ORCID: https://orcid.org/0000-0001-8036-0855)
- Yan Cheng (ORCID: https://orcid.org/0000-0003-4169-307X)
- Jing Hu (ORCID: https://orcid.org/0000-0002-4119-4564)
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.83166.17982
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00